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Injecting in the same spot repeatedly can cause lipodystrophy, a condition where fat either builds up abnormally or atrophies, potentially affecting medication absorption

doi: 10.1172/JCI104862 56 WartofskyLBurmanKDAlterations in thyroid function in patients with systemic illness: The Euthyroid sick syndrome. Endocr Rev (1982) 3:164217 doi: 10.1210/edrv-3-2-164 57 FliersEBoelenA

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After first use, the pen may be kept at room temperature (below 30C / 86F) or refrigerated for up to 56 days

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